Elvis Twumasi Aboagye (PhD)
Adjunct: Biochemistry
My PhD in Biochemistry at the University of Ghana investigated the genetic architecture of non-syndromic deafness in Ghana. The study used cell-base experimentation and population genetic tools to generate useful insights into the heritable and de novo genetic factors responsible for this highly penetrant and heterogenous condition. Exome sequenced data revealed segregation of known and candidate genes among families studied. Prior to this degree, with BSc in Biochemistry obtained from the University for Development Studies, Tamale, I investigated the clinical and genetic risk factors of Nevirapine hypersensitivity reactions among naïve antiretroviral therapy HIV patients at the Korle-Bu Teaching Hospital for my MPhil. in Medical Biochemistry degree (University of Ghana). This pharmacogenetics study illuminated the contribution and prevalence of CYP2B*6 to Nevirapine hypersensitivity in participants studied. To this end, I had conducted post-doctoral research study at the Division of Human Genetics, Department of Pathology, University of Cape Town, South Africa, with research that focused on genomics of deafness in African populations. During this period, I designed, coordinated, and supervised a multi-country (Ghana, South Africa, Mali, Senegal, Rwanda, and Cameroon) deafness cohorts functional genetic characterization study on identified novel and candidate deafness genes in the Genetic Medicine of African Populations (GeneMAP) group at the Division of Human Genetics, University of Cape Town, South Africa. I am passionate about life sciences and teaching, with research interest that includes harnessing patient/disease-derived induced pluripotent stem cells (iPSCs) and three-dimensional organoid models to elucidate underlying molecular mechanisms, pathways, therapeutic targets, and inherent modifiers leading to the spectrum of phenotype manifestation. On translation and implementation research, I have interest in the correlates of cochlear implant outcomes and post-surgery residual hearing preservation. I am open for research collaboration and concept exploration on functional genomics, systems biology, pharmacogenomics, infectious and neglected tropical diseases.
- General Chemistry
- Functional Genomics
- Systems Biology
- Bioinformatics
- Pharmacogenomics
- Infectious and Neglected Tropical Diseases
- Aboagye, E. T, Adadey, S. M., Alves de Souza Rios, L., Esoh, K. K., Wonkam-Tingang, E., Xhakaza, L., De Kock, C., Schrauwen, I., Amenga-Etego, L., Lang, D., Awandare, G. A., Leal, S. M., Mowla, S., & Wonkam, A. (2025). Bi-Allelic MARVELD2 Variant Identified with Exome Sequencing in a Consanguineous Multiplex Ghanaian Family Segregating Non-Syndromic Hearing Loss. International Journal of Molecular Sciences, 26(7), 3337. https://doi.org/10.3390/ijms26073337. 2.
- Bharadwaj, T., Acharya, A., Manyisa, N. R., Aboagye, E. T., Peigou Wonkam, R., Xhakaza, L., Popel, K., De Kock, C., Schrauwen, I., Wonkam, A., & Leal, S. M. (2025). The Diverse Genetic Landscape of Hearing Impairment in South African Families. Clinical Genetics, cge.14765. https://doi.org/10.1111/cge.14765.
- Aboagye, E. T., Adadey, S. M., Wonkam-Tingang, E., Amenga-Etego, L., Awandare, G. A., & Wonkam, A. (2023). Global Distribution of Founder Variants Associated with Non-Syndromic Hearing Impairment. Genes, 14(2), Article 2. https://doi.org/10.3390/genes14020399.
- Aboagye, E. T., Adadey, S. M., Esoh, K., Jonas, M., de Kock, C., Amenga-Etego, L., Awandare, G. A., & Wonkam, A. (2022). Age Estimate of GJB2-p.(Arg143Trp) Founder Variant in Hearing Impairment in Ghana, Suggests Multiple Independent Origins across Populations. Biology, 11(3), 476. https://doi.org/10.3390/biology11030476.
- Wonkam, A., Adadey, S. M., Schrauwen, I., Aboagye, E. T., Wonkam-Tingang, E., Esoh, K., Popel, K., Manyisa, N., Jonas, M., deKock, C., Nembaware, V., Cornejo Sanchez, D. M., Bharadwaj, T., Nasir, A., Everard, J. L., Kadlubowska, M. K., Nouel-Saied, L. M., Acharya, A., Quaye, O., … Leal, S. M. (2022). Exome sequencing of families from Ghana reveals known and candidate hearing impairment genes. Communications Biology, 5(1), 1–16. https://doi.org/10.1038/s42003-022-03326-8
- PhD Biochemistry, University of Ghana, Legon-Accra, Ghana
- MPhil Medical Biochemistry, University of Ghana, Korle-Bu Accra, Ghana
- BSc Biochemistry, University for Development Studies, Tamale, Ghana.
